Chang DJ, P L S, Jeong J, Saw SM, Sevdalis N, Najjar RP.

Light Therapy for Myopia Prevention and Control: A Systematic Review on Effectiveness, Safety, and Implementation.

Transl Vis Sci Technol. 2024 Aug 1;13(8):31. doi: 10.1167/tvst.13.8.31. PMID: 39167378

J Pineal Res. 2024
Jan;76(1):e12930. doi: 10.1111/jpi.12930. PMID: 38241677.

Hartstein LE, LeBourgeois MK, Durniak MT, Najjar RP.

Differences in the pupillary responses to evening light between children and adolescents.

J Physiol Anthropol. 2024 Jul 3;43(1):16. doi: 10.1186/s40101-024-00363-6. PMID: 38961509

J Pineal Res. 2024
Jan;76(1):e12930. doi: 10.1111/jpi.12930. PMID: 38241677.

Biswas S, El Kareh A, Qureshi M, Lee DMX, Sun CH, Lam JSH, Saw SM, Najjar RP.

The influence of the environment and lifestyle on myopia.

J Physiol Anthropol. 2024 Jan 31; 43(1):7. doi: 10.1186/s40101-024-00354-7. PMID: 38297353

J Pineal Res. 2024
Jan;76(1):e12930. doi: 10.1111/jpi.12930. PMID: 38241677.

Najjar RP, Prayag AS, Gronfier C

Melatonin suppression by light involves different retinal photoreceptors in young and older adults

J Pineal Res. 2024 Jan; 76(1):e12930. doi: 10.1111/jpi.12930. PMID: 38241677.

J Pineal Res. 2024
Jan;76(1):e12930. doi: 10.1111/jpi.12930. PMID: 38241677.

Lin MY, Najjar RP, Tang Z, Cioplean D, Dragomir M, Chia A, Patil A, Vasseneix C, Peragallo JH, Newman NJ, Biousse V, Milea D; BONSAI (Brain and Optic Nerve Study with Artificial Intelligence) group. 

The BONSAI (Brain and Optic Nerve Study with Artificial Intelligence) deep learning system can accurately identify pediatric papilledema on standard ocular fundus photographs

J AAPOS. 2024 Jan 10:S1091-8531(24)00003-X. doi: 10.1016/j.jaapos.2023.10.005. Epub ahead of print. PMID: 38216117.

J Pineal Res. 2024
Jan;76(1):e12930. doi: 10.1111/jpi.12930. PMID: 38241677.

Spitschan M, Kervezee L, Lok R, McGlashan E, Najjar RP; ENLIGHT Consortium.

ENLIGHT: A consensus checklist for reporting laboratory-based studies on the non-visual effects of light in humans

EBioMedicine. 2023 Dec;98:104889. doi: 10.1016/j.ebiom.2023.104889. Epub 2023 Dec 2. PMID: 38043137; PMCID: PMC10704221.

Biousse V, Najjar RP, Tang Z, Lin MY, Wright DW, Keadey MT, Wong TY, Bruce BB, Milea D, Newman NJ; BONSAI Study Group

Application of a deep learning system to detect papilledema on nonmydriatic ocular fundus photographs in an emergency department

Am J Ophthalmol. 2023 Nov 4:S0002-9394(23)00456-7. doi: 10.1016/j.ajo.2023.10.025. Epub ahead of print. PMID: 37926337.

Tan RKY, Panda SK, Braeu FA, Muralidharan AR, Nongpiur ME, Chan ASY, Aung T, Najjar RP, Girard MJA

The Structural Layers of the Porcine Iris Exhibit Inherently Different Biomechanical Properties

Invest Ophthalmol Vis Sci. 2023 Oct 3;64(13):11. doi: 10.1167/iovs.64.13.11. PMID: 37796489; PMCID: PMC10561784

Foo LL, Tan CS, Noel B, Htoon HM, Najjar RP, Kathrani B, Sabanayagam C, Saw SM

Factors influencing myopia stabilisation in young myopic adult Singaporeans

Br J Ophthalmol. 2023 Aug 27:bjo-2023-323680. doi: 10.1136/bjo-2023-323680. Epub ahead of print. PMID: 37640399

Finkelstein MT, Nongpiur ME, Husain R, Perera S, Baskaran M, Wong TT, Aung T, Milea D, Najjar RP

Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia

Br J Ophthalmol. 2023 Jul 31:bjo-2023-323878. doi: 10.1136/bjo-2023-323878. Epub ahead of print. PMID:37524446.

Liu X, Jiang L, Ke M, Sigal IA, Chua J, Hoang QV, Chia AW, Najjar RP, Tan B, Cheong J, Bellemo V, Chong RS, Girard MJA, Ang M, Liu M, Garhöfer G, Barathi VA, Saw SM, Villiger M, Schmetterer L

Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression

Nat Biomed Eng. 2023 Aug;7(8):986-1000. doi: 10.1038/s41551-023-01062-w. Epub 2023 Jun 26. PMID: 37365268; PMCID: PMC10427432

Biswas S, Muralidharan AR, Betzler BK, Busoy JMF, Barathi VA, Tan RKY, Low WYS, Milea D, Kathrani BK, Brennan NA, Najjar RP

A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive
for Myopia Control

Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):31. doi:10.1167/iovs.64.3.31. PMID: 36951855; PMCID: PMC10050902.

Sathianvichitr K, Lamoureux O, Nakada S, Tang Z, Schmetterer L, Chen C, Cheung CY, Najjar RP, Milea D

Through the eyes into the brain, using artificial intelligence

Ann Acad Med Singap. 2023 Feb;52(2):88-95. doi: 10.47102/annals-acadmedsg.2022369. PMID: 36880820

Vasseneix C, Nusinovici S, Xu X, Hwang JM, Hamann S, Chen JJ, Loo JL, Milea L, Tan KBK, Ting DSW, Liu Y, Newman NJ, Biousse V, Wong TY, Milea D, Najjar RP; BONSAI (Brain and Optic Nerve Study With Artificial Intelligence) Group

Deep Learning System Outperforms Clinicians in Identifying Optic Disc Abnormalities

J Neuroophthalmol. 2023 Jun 1;43(2):159-167. doi: 10.1097/WNO.0000000000001800.
Epub 2023 Feb 1. PMID: 36719740

Girard MJA, Panda S, Tun TA, Wibroe EA, Najjar RP, Aung T, Thiéry AH, Hamann S, Fraser C, Milea D

Discriminating Between Papilledema and Optic Disc Drusen Using 3D Structural Analysis of the Optic Nerve Head

Neurology. 2023 Jan 10;100(2):e192-e202. doi: 10.1212/WNL.0000000000201350. Epub 2022 Sep 29. PMID:36175153

Sia JT, Lee EPX, Cheung CMG, Fenwick EK, Laude A, Ho KC, Fenner BJ, Wong TY, Milea D, Lamoureux EL, Man REK, Najjar RP

Associations between age-related macular degeneration and sleep dysfunction: A systematic review

Clin Exp Ophthalmol. 2022 Dec;50(9):1025-1037. doi: 10.1111/ceo.14146. Epub 2022 Aug 31.
PMID: 36054031

Tan TE, Finkelstein MT, Tan GSW, Tan ACS, Chan CM, Mathur R, Wong EYM, Cheung CMG, Wong TY, Milea D, Najjar RP

Retinal neural dysfunction in diabetes revealed with handheld chromatic pupillometry

Clin Exp Ophthalmol. 2022 Sep;50(7):745-756. doi: 10.1111/ceo.14116. Epub 2022 Jun 13. PMID: 35616273; PMCID: PMC9796882

Leong YY, Vasseneix C, Finkelstein MT, Milea D, Najjar RP

Artificial Intelligence Meets Neuro-Ophthalmology

Asia Pac J Ophthalmol (Phila). 2022 Mar-Apr 01;11(2):111-125. doi: 10.1097/APO.0000000000000512. PMID: 35533331

Muralidharan AR, Low SWY, Lee YC, Barathi VA, Saw SM, Milea D, Najjar RP

Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum

Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):16. doi: 10.1167/iovs.63.2.16. PMID: 35133400; PMCID: PMC8822367

Muralidharan AR, Lança C, Biswas S, Barathi VA, Wan Yu Shermaine L, Seang-Mei S, Milea D, Najjar RP

Light and myopia: from epidemiological studies to neurobiological mechanisms

Ther Adv Ophthalmol. 2021 Dec 19;13:25158414211059246. doi: 10.1177/25158414211059246. PMID: 34988370; PMCID: PMC8721425

Najjar RP, Rukmini AV, Finkelstein MT, Nusinovici S, Mani B, Nongpiur ME, Perera S, Husain R, Aung T, Milea D

Handheld chromatic pupillometry can accurately and rapidly reveal functional loss in glaucoma

Br J Ophthalmol. 2023 May;107(5):663-670. doi: 10.1136/bjophthalmol-2021-319938. Epub 2021 Dec 1.
PMID: 34853018; PMCID: PMC10176376

Finkelstein MT*, Najjar RP*, Chougule P, Mathur R, Milea D

Chromatic pupillometry in multiple evanescent white dot syndrome masquerading as atypical optic neuritis

Acta Ophthalmol. 2022 Sep;100(6):713-715. doi: 10.1111/aos.14998. Epub 2021 Aug 19. PMID: 34411454

Vasseneix C, Najjar RP, Xu X, Tang Z, Loo JL, Singhal S, Tow S, Milea L, Ting DSW, Liu Y, Wong TY, Newman NJ, Biousse V, Milea D; BONSAI Group

Accuracy of a Deep Learning System for Classification of Papilledema Severity on Ocular Fundus Photographs

Neurology. 2021 Jul 27;97(4):e369-e377. doi: 10.1212/WNL.0000000000012226. Epub 2021 May 19. PMID: 34011570; PMCID: PMC8362357

Najjar RP, Chao De La Barca JM, Barathi VA, Ho CEH, Lock JZ, Muralidharan AR, Tan RKY, Dhand C, Lakshminarayanan R, Reynier P, Milea D

Ocular growth and metabolomics are dependent upon the spectral content of ambient white light

Sci Rep. 2021 Apr 7;11(1):7586. doi: 10.1038/s41598-021-87201-2. PMID: 33828194; PMCID: PMC8026599

Biousse V*, Newman NJ*, Najjar RP*, Vasseneix C, Xu X, Ting DS, Milea LB, Hwang JM, Kim DH, Yang HK, Hamann S, Chen JJ, Liu Y, Wong TY, Milea D; BONSAI (Brain and Optic Nerve Study with Artificial Intelligence) Study Group

Optic Disc Classification by Deep Learning versus Expert Neuro-Ophthalmologists

Ann Neurol. 2020 Oct;88(4):785-795. doi: 10.1002/ana.25839. Epub 2020 Aug 7. PMID: 32621348

Milea D*, Najjar RP*, Zhubo J, Ting D, Vasseneix C, Xu X, Aghsaei Fard M, Fonseca P, Vanikieti K, Lagrèze WA, La Morgia C, Cheung CY, Hamann S, Chiquet C, Sanda N, Yang H, Mejico LJ, Rougier M-B, Kho R, Thi Ha Chau T, Singhal S, Gohier P, Clermont-Vignal C, Cheng C-Y, Jonas JB, Yu-Wai-Man P, Fraser CL, Chen JJ, Ambika S, Miller NR, Liu Y, Newman NJ, Wong TY, Biousse V; BONSAI Group

Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs

N Engl J Med. 2020 Apr 30;382(18):1687-1695. doi: 10.1056/NEJMoa1917130. Epub 2020 Apr 14. PMID: 32286748

Lanca C, Teo A, Vivagandan A, Htoon HM, Najjar RP, Spiegel DP, Pu SH, Saw SM

The Effects of Different Outdoor Environments, Sunglasses and Hats on Light Levels: Implications for Myopia Prevention

Transl Vis Sci Technol. 2019 Jul 18;8(4):7. doi: 10.1167/tvst.8.4.7. PMID: 31360613; PMCID: PMC6656201

Chougule PS, Najjar RP, Finkelstein MT, Kandiah N, Milea D

Light-Induced Pupillary Responses in Alzheimer’s Disease

Front Neurol. 2019 Apr 12;10:360. doi: 10.3389/fneur.2019.00360. PMID: 31031692; PMCID: PMC6473037

Teikari P, Najjar RP, Schmetterer L, Milea D

Embedded deep learning in ophthalmology: making ophthalmic imaging smarter

Ther Adv Ophthalmol. 2019 Mar 19;11:2515841419827172. doi: 10.1177/2515841419827172. PMID: 30911733; PMCID: PMC6425531

Rukmini AV, Chew MC, Finkelstein MT, Atalay E, Baskaran M, Nongpiur ME, Gooley JJ, Aung T, Milea D, Najjar RP

Effects of low and moderate refractive errors on chromatic pupillometry

Sci Rep. 2019 Mar 20;9(1):4945. doi: 10.1038/s41598-019-41296-w. PMID: 30894608; PMCID: PMC6426861

Calligaro H, Coutanson C, Najjar RP, Mazzaro N, Cooper HM, Haddjeri N, Felder-Schmittbuhl MP, Dkhissi-Benyahya O

Rods contribute to the light-induced phase shift of the retinal clock in mammals

PLoS Biol. 2019 Mar 1;17(3):e2006211. doi: 10.1371/journal.pbio.2006211. PMID: 30822304; PMCID:
PMC6415865

Prayag AS, Najjar RP, Gronfier C

Melatonin suppression is exquisitely sensitive to light and primarily driven by melanopsin in humans

J Pineal Res. 2019 May;66(4):e12562. doi: 10.1111/jpi.12562. Epub 2019 Mar 1. PMID: 30697806

Najjar RP, Sharma S, Atalay E, Rukmini AV, Sun C, Lock JZ, Baskaran M, Perera SA, Husain R, Lamoureux E, Gooley JJ, Aung T, Milea D

Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-
Stage Primary Open-Angle Glaucoma

Ophthalmology. 2018 Sep;125(9):1362-1371. doi: 10.1016/j.ophtha.2018.02.024. Epub 2018 Mar 21. PMID: 29573814

Najjar RP, Sharma S, Drouet M, Leruez S, Baskaran M, Nongpiur ME, Aung T, Fielding J, White O, Girard MJ, Lamirel C, Milea D

Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma

Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2430-2437. doi: 10.1167/iovs.16-21002. PMID: 28448671

Najjar RP, Zeitzer JM

Temporal integration of light flashes by the human circadian system

J Clin Invest. 2016 Mar 1;126(3):938-47. doi: 10.1172/JCI82306. Epub 2016 Feb 8. PMID: 26854928; PMCID: PMC4767340

Najjar RP, Wolf L, Taillard J, Schlangen LJ, Salam A, Cajochen C, Gronfier C

Chronic artificial blue-enriched white light is an effective countermeasure to delayed circadian phase and neurobehavioral decrements

PLoS One. 2014 Jul 29;9(7):e102827. doi: 10.1371/journal.pone.0102827. PMID: 25072880; PMCID:
PMC4114570

Najjar RP, Chiquet C, Teikari P, Cornut PL, Claustrat B, Denis P, Cooper HM, Gronfier C

Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?

PLoS One. 2014 Jan 23;9(1):e85837. doi: 10.1371/journal.pone.0085837. PMID: 24465738; PMCID: PMC3900444

Teikari P*, Najjar RP*, Knoblauch K, Dumortier D, Cornut PL, Denis P, Cooper HM, Gronfier C

Refined flicker photometry technique to measure ocular lens density

J Opt Soc Am A Opt Image Sci Vis. 2012 Nov 1;29(11):2469-78. doi: 10.1364/JOSAA.29.002469. PMID: 23201811

Teikari P, Najjar RP, Malkki H, Knoblauch K, Dumortier D, Gronfier C, Cooper HM

An inexpensive Arduino-based LED stimulator system for vision research

J Neurosci Methods. 2012 Nov 15;211(2):227-36. doi: 10.1016/j.jneumeth.2012.09.012. Epub 2012 Sep 21. PMID: 23000405